Bloodhound Cross Mastiff: Complete Guide to This Giant Mixed Breed
Everything about the bloodhound cross mastiff: size, temperament, health risks, grooming, cost, and whether this giant designer mix fits your lifestyle.
What Exactly Is a Bloodhound Cross Mastiff?
A bloodhound cross mastiff is a first-generation or multigenerational mix between a purebred Bloodhound and a purebred Mastiff (most commonly the English Mastiff, though some breeders use Bullmastiff or Neapolitan Mastiff lines). This is not an AKC-recognized breed — it falls into the designer or mixed-breed category, meaning each individual dog can look, behave, and mature quite differently from its littermates.
With the bloodhound's legendary scent-tracking ability and the Mastiff's imposing guardian presence, this cross produces one of the largest companion dogs you'll encounter. Adults routinely exceed 120 pounds, and some males push past 180 pounds. That sheer scale makes this mix a serious commitment in terms of space, food budget, veterinary costs, and training time.
Before we break down what to expect, let's look at the two parent breeds side by side.
| Trait | Bloodhound | English Mastiff |
|---|---|---|
| AKC Group | Hound | Working |
| Weight Range | 80–110 lb (36–50 kg) | 120–230 lb (54–104 kg) |
| Height at Shoulder | 23–27 in (58–69 cm) | 27.5–30+ in (70–76+ cm) |
| Lifespan | 10–12 years | 6–10 years |
| Coat | Short, dense, hard | Short, straight, coarse outer with dense undercoat |
| Energy Level | Moderate (endurance-based) | Low to moderate |
| Primary Instinct | Scent tracking | Guarding / protection |
| Drool Factor | High | Very high |
| Trainability | Moderate (independent thinker) | Moderate (willing but sensitive) |
Both parent breeds share traits like heavy drooling, deep loyalty, and a calm indoor demeanor — but they diverge significantly on instinct and drive. A Bloodhound will follow a scent trail for miles; a Mastiff is more likely to plant itself between you and a stranger. Where your mixed dog falls on that spectrum is partly a genetic coin flip.
How Big Will a Bloodhound Cross Mastiff Get?
This is one of the heaviest designer mixes in existence. Because both parent breeds are large to giant, you can expect substantial size — but the exact number depends on which parent the dog takes after more, as well as sex and individual genetics.
| Category | Weight | Height at Shoulder |
|---|---|---|
| Small end (female, Bloodhound-leaning) | 90–120 lb (41–54 kg) | 24–27 in (61–69 cm) |
| Average adult | 130–160 lb (59–73 kg) | 26–29 in (66–74 cm) |
| Large end (male, Mastiff-leaning) | 160–200+ lb (73–91+ kg) | 28–32 in (71–81 cm) |
Growth is slow. Like most giant breeds, a bloodhound cross mastiff won't reach full skeletal maturity until 18 to 24 months, and some males continue filling out in chest and muscle mass until age three. During growth, keep exercise controlled — avoid forced running, jumping from heights, or long stair sessions to protect developing joints. The AKC recommends monitoring giant-breed puppies with regular weight checks and adjusting nutrition to avoid overly rapid growth, which increases hip dysplasia risk.
Generations Explained: F1, F1B, and Beyond
Generation Guide for Designer Mixes
F1 (First Generation): One purebred Bloodhound × one purebred Mastiff. Maximum genetic diversity, but highest trait variability — puppies in the same litter can look dramatically different.
F1B (First Generation Backcross): An F1 bloodhound cross mastiff bred back to one of the parent breeds (e.g., F1 × Mastiff). This pushes traits closer to the backcross parent — useful if you want more predictable size or temperament leaning one direction.
F2 (Second Generation): Two F1 bloodhound cross mastiffs bred together. This produces the widest variability of all generations because recessive genes from both breeds can recombine unpredictably. F2 litters are the least predictable.
Multigen (F3+): Multiple generations of bloodhound cross mastiff bred to bloodhound cross mastiff. Very rare for this particular mix — most breeders stick with F1 pairings because the market for this cross is small.
For this mix, the vast majority of available dogs are F1 crosses — typically an accidental or intentional pairing of two purebred parents. Multigenerational breeding programs for bloodhound cross mastiffs are essentially nonexistent as of 2026, so don't expect to find established "lines" the way you would with Labradoodles or Goldendoodles. Most dogs sold under this name are one-off litters.
Temperament: What to Expect (and What Might Surprise You)
Temperament is where the genetic lottery matters most. Both parent breeds are generally gentle, loyal, and good with their families — but they express those qualities very differently.
Best-Case Temperament Scenario
Your dog inherits the Mastiff's calm, watchful steadiness combined with the Bloodhound's friendly, people-oriented nature. The result: a large, confident dog that greets visitors warmly but remains alert, is deeply bonded to its family, tolerates children well, and settles quietly indoors. This dog is trainable with patience and food motivation, walks politely on leash, and doesn't show reactivity toward strangers or other dogs.
Challenging Temperament Scenario
Your dog inherits the Bloodhound's powerful scent drive and independence alongside the Mastiff's guardian instinct and size. The result: a 150-pound dog that pulls relentlessly on leash when it catches an interesting smell, bays loudly (Bloodhounds are among the most vocal breeds), becomes stubbornly immovable when it wants to follow a trail, and may show wariness or protective behavior toward strangers entering the home. This combination at full size requires an experienced handler, a securely fenced yard (minimum 6-foot fence), and committed positive-reinforcement training from puppyhood.
Key Temperament Variables
- Vocalization: Bloodhounds bay — a deep, resonant howl that carries for long distances. If your mix inherits this trait, it's not a good fit for apartments or close-quarter neighborhoods. Mastiffs tend toward deep barks rather than baying.
- Stranger response: Ranges from tail-wagging greeting (Bloodhound-leaning) to watchful positioning between owner and stranger (Mastiff-leaning).
- Prey drive: Bloodhounds have moderate prey drive focused on scent following. Mastiffs have variable prey drive. Most crosses do fine with cats if socialized early, but squirrels and rabbits may trigger chasing.
- Separation tolerance: Both breeds bond closely to their people. Expect potential separation anxiety if left alone for 8+ hours regularly. This is not a dog you can leave in a crate all day — giant breeds need space to move and shift position.
Coat, Shedding, and Grooming Realities
Good news on one front: neither parent breed has a complicated coat. Both are short-haired, and the bloodhound cross mastiff will almost certainly inherit a short, dense coat that requires minimal styling. There is no long-coat or curly-coat gene in either breed, so you won't face professional grooming bills.
Shedding Expectations
This mix is not hypoallergenic and not low-shedding. Both Bloodhounds and Mastiffs are moderate to heavy seasonal shedders. Expect year-round light shedding with two heavier "blow" periods in spring and fall. Dark-colored dogs (black-and-tan Bloodhound coloring or fawn Mastiff coloring) will leave visible hair on furniture and clothing.
Grooming Routine
| Task | Frequency | Details |
|---|---|---|
| Brushing | 2–3× per week | Rubber curry brush or bristle brush (e.g., Kong ZoomGroom or Furminator short-hair tool) |
| Bathing | Every 6–8 weeks or as needed | Use a gentle oatmeal-based dog shampoo; Bloodhound skin folds need careful drying |
| Skin fold care | Daily to every other day | If the dog inherits Bloodhound-style facial wrinkles, wipe folds with a damp cloth and dry thoroughly to prevent yeast/bacterial infection (intertrigo) |
| Ear cleaning | Weekly | Both breeds have pendant (drop) ears prone to infection. Clean with a vet-approved ear wash (e.g., Epi-Otic Advanced); dry thoroughly |
| Nail trimming | Every 2–3 weeks | |
| Drool management | Constant | Keep drool rags handy. Both breeds are prolific droolers — this mix will sling saliva, especially after drinking, eating, or exercise |
The skin fold point deserves emphasis. Bloodhounds have significant facial wrinkling, and if your cross inherits deep folds, those creases trap moisture and debris. Intertrigo (skin fold pyoderma) is common in wrinkled breeds and requires consistent hygiene — not just occasional wiping.
Health Considerations: Hybrid Vigor vs. Reality
Let's address the hybrid vigor myth directly. Crossbreeding does increase genetic diversity, which can reduce the risk of recessive inherited diseases that require two copies of a defective gene. However, hybrid vigor does not eliminate health problems that both parent breeds share. When both a Bloodhound and a Mastiff are predisposed to the same condition, their cross is equally at risk — possibly more so, because you're combining two giant-breed skeletal systems.
Conditions Inherited from Both Parents
- Hip dysplasia: Extremely common in both breeds. The Orthopedic Foundation for Animals (OFA) reports hip dysplasia rates of approximately 20% in Bloodhounds and 24% in Mastiffs. Your cross has a meaningful risk of developing this degenerative joint condition.
- Elbow dysplasia: Both breeds carry risk. Giant-breed elbow dysplasia can manifest as early as 4–6 months.
- Gastric dilatation-volvulus (GDV / bloat): Both deep-chested giant breeds are among the highest-risk breeds for bloat, a life-threatening emergency where the stomach fills with gas and twists. The AVMA identifies large, deep-chested breeds as the primary risk group.
- Dilated cardiomyopathy (DCM): Both breeds have documented DCM risk, a progressive heart muscle disease.
Conditions from the Bloodhound Side
- Ectropion / entropion: Eyelid abnormalities related to loose facial skin — eyelids rolling outward (ectropion) or inward (entropion), causing irritation or corneal damage.
- Hypothyroidism: Relatively common in Bloodhounds; manageable with daily thyroid hormone replacement.
- Ear infections (otitis externa): Heavy, pendant ears trap moisture and debris.
Conditions from the Mastiff Side
- Osteosarcoma: Mastiffs have one of the highest rates of bone cancer among all breeds. Typically appears in dogs aged 7–10. Prognosis is guarded even with amputation and chemotherapy.
- Cystinuria: A hereditary kidney stone condition documented in English Mastiffs.
- Cruciate ligament rupture (CCL): The giant-breed equivalent of an ACL tear in humans. Surgical repair (TPLO or TTA) costs $3,000–$6,000 per knee.
- Ask the breeder for OFA or PennHIP hip scores on both parents
- Request cardiac clearance (OFA cardiologist exam) for both parents
- Discuss prophylactic gastropexy (stomach tacking) with your veterinarian at the time of spay/neuter — this surgery dramatically reduces GDV risk and is strongly recommended for giant deep-chested dogs
- Budget for annual orthopedic X-rays starting at age 3–4 to monitor joint health
- Feed a large-breed or giant-breed formula through adulthood to support joint nutrition (look for added glucosamine, chondroitin, and omega-3 fatty acids)
Lifespan Expectations
Giant breeds live shorter lives. Bloodhounds average 10–12 years; English Mastiffs average 6–10 years. A bloodhound cross mastiff's lifespan will likely fall in the 8–11 year range, depending on which parent's longevity genes dominate and how well you manage weight, joint health, and cancer screening.
Cost Breakdown: Purchase Price and Lifetime Expenses
This is an expensive dog to acquire and maintain. Here's a realistic financial picture.
Acquisition Cost
| Source | Price Range | Notes |
|---|---|---|
| Intentional breeder (F1 cross) | $800–$2,000 | Relatively rare cross; most breeders focus on more popular designer mixes. Verify health testing on both parents. |
| Accidental litter / backyard breeder | $200–$600 | No health testing, no take-back guarantee, unknown genetic background. High risk. |
| Rescue / shelter adoption | $50–$400 | Giant mixed breeds do end up in rescue, often surrendered when owners underestimate adult size. Check large-breed-specific rescues and Mastiff/Bloodhound breed rescues. |
Annual Care Costs (Estimated)
| Expense Category | Annual Cost |
|---|---|
| Food (giant-breed formula) | $960–$1,680 |
| Preventive medications (heartworm, flea/tick) | $300–$500 (giant-breed doses cost more) |
| Routine veterinary care (exams, bloodwork, vaccines) | $400–$700 |
| Pet insurance (giant breed, comprehensive) | $900–$1,800 |
| Grooming supplies and ear care | $100–$200 |
| Joint supplements (glucosamine/chondroitin/MSM) | $150–$300 |
| Miscellaneous (toys, bedding, crate, leashes) | $200–$400 |
Total estimated annual cost: $3,000–$5,500+ — and this doesn't include emergency care. A single bloat surgery can cost $5,000–$10,000; TPLO surgery for a torn cruciate runs $3,000–$6,000 per knee. Pet insurance or a dedicated emergency fund is strongly recommended.
Who Should (and Shouldn't) Get a Bloodhound Cross Mastiff?
This mix is not a beginner dog, and it's not a casual commitment. Here's a practical fit assessment.
This Mix Suits You If:
- You have prior experience with giant breeds or large working/hound dogs
- You live in a house with a securely fenced yard (minimum 6-foot fence, no gaps — Bloodhounds are notorious escapers when on a scent)
- You can dedicate 45–90 minutes daily to structured walks and mental enrichment (scent games, tracking exercises, puzzle feeders)
- You have the financial capacity for giant-breed veterinary care, including potential orthopedic surgeries
- You don't mind drool, shedding, and a dog that takes up an entire couch
- You're prepared for positive-reinforcement training from puppyhood through adolescence (which in giant breeds lasts until 2–3 years of age)
- Your children are old enough (8+) to interact safely with a dog that may weigh more than they do
Look for a Different Breed If:
- You live in an apartment or have close neighbors sensitive to deep baying/barking
- This would be your first dog
- You work long hours away from home with no dog walker or daycare option
- You want a low-maintenance, low-drool, low-shed companion
- Your household budget can't absorb $3,000–$5,000+ in annual dog costs or a potential $10,000 emergency surgery
- You prefer off-leash hiking — neither parent breed is reliable off-leash (scent drive and guardian instinct override recall)
Frequently Asked Questions
What two breeds make up a bloodhound cross mastiff?
A purebred Bloodhound and a purebred Mastiff — most commonly the English Mastiff, though Bullmastiff or Neapolitan Mastiff are occasionally used. The result is an F1 designer cross, not a recognized breed.
How big will a bloodhound cross mastiff get?
Adults typically range from 90 to 200+ pounds (41–91+ kg) and stand 24–32 inches (61–81 cm) at the shoulder. Females and Bloodhound-leaning individuals fall on the smaller end; males and Mastiff-leaning individuals can exceed 180 pounds. Full growth takes 18–24 months.
What will the temperament be like?
Expect a loyal, people-oriented dog with moderate-to-high independence. The mix may lean toward the Bloodhound's scent-driven, vocal nature or the Mastiff's calm, watchful guardian style — or land somewhere in between. Early socialization and consistent positive-reinforcement training are essential regardless of which direction the temperament leans.
Is this mix hypoallergenic or low-shedding?
No. Both parent breeds have short coats that shed moderately year-round with heavier seasonal shedding. Neither breed carries hypoallergenic coat genes. If you have dog allergies, this cross is not a good choice.
What health issues might this mix inherit?
Shared risks include hip dysplasia, elbow dysplasia, gastric dilatation-volvulus (bloat), and dilated cardiomyopathy. Bloodhound-specific risks include eyelid abnormalities and hypothyroidism; Mastiff-specific risks include osteosarcoma and cystinuria. Consult your veterinarian about a breed-appropriate screening schedule and discuss prophylactic gastropexy to reduce bloat risk.
How much does a bloodhound cross mastiff cost?
Expect $800–$2,000 from an intentional breeder, $200–$600 from an accidental litter, or $50–$400 through rescue adoption. Annual care costs run $3,000–$5,500+ for food, preventive medications, veterinary care, insurance, and supplies.
Are bloodhound cross mastiffs good with children?
Generally yes — both parent breeds are known for patience with children in their own family. However, a 150-pound dog can accidentally knock over a toddler, and both breeds can be clumsy. Supervise all interactions, teach children how to read canine body language, and ensure the dog has a child-free retreat space.
How much exercise does this mix need?
Plan for 45–90 minutes of daily activity, split into two or more sessions. This should include structured leash walks, scent-work games (which tire a hound-brain faster than physical exercise alone), and supervised yard time. Avoid high-impact exercise (running on hard surfaces, jumping) until skeletal maturity at 18–24 months.
Dr. Hannah Wickes
All our authors care for dogs every day — read more of their work on the authors page.
